Dosage In Adults:
The recommended starting dose is 1 mg. Dosing can be raised to 2 mg or 3 mg if clinically indicated. In some patients, the higher morning blood levels of LUNESTA following use of the 2 mg or 3 mg dose increase the risk of next day impairment of driving and other activities that require full alertness. The total dose of LUNESTA should not exceed 3 mg, once daily immediately before bedtime.
Geriatric Or Debilitated Patients:
The total dose of LUNESTA should not exceed 2 mg in elderly or debilitated patients.
Patients With Severe Hepatic Impairment:
In patients with severe hepatic impairment the total dose of LUNESTA should not exceed 2 mg.
Use With CNS Depressants:
Dosage adjustments may be necessary when LUNESTA is combined with other CNS depressant drugs because of the potentially additive effects.
Administration With Food:
Taking LUNESTA with or immediately after a heavy, high-fat meal results in slower absorption and would be expected to reduce the effect of LUNESTA on sleep latency